منابع مشابه
Molecular and Functional Profiling of Memory CD8 T Cell Differentiation
How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. ...
متن کاملEarly events governing memory CD8+ T-cell differentiation.
Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of...
متن کاملDistinct effects of saracatinib on memory CD8+ T cell differentiation.
Immunologic memory involving CD8(+) T cells is a hallmark of an adaptive Ag-specific immune response and constitutes a critical component of protective immunity. Designing approaches that enhance long-term T cell memory would, for the most part, fortify vaccines and enhance host protection against infectious diseases and, perhaps, cancer immunotherapy. A better understanding of the cellular pro...
متن کاملEpitope Density Influences CD8+ Memory T Cell Differentiation
BACKGROUND The generation of long-lived memory T cells is critical for successful vaccination but the factors controlling their differentiation are still poorly defined. We tested the hypothesis that the strength of T cell receptor (TCR) signaling contributed to memory CD8(+) T cell generation. METHODOLOGY/PRINCIPAL FINDINGS We manipulated the density of antigenic epitope presented by dendrit...
متن کاملDiscriminating between different pathways of memory CD8+ T cell differentiation.
Despite the rapid accumulation of quantitative data on the dynamics of CD8(+) T cell responses following acute viral or bacterial infections of mice, the pathways of differentiation of naive CD8(+) T cells into memory during an immune response remain controversial. Currently, three models have been proposed. In the "stem cell-associated differentiation" model, following activation, naive T cell...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2010
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2009.05126.x